Low dose radiation to treat dilated cardiomyopathy and congestive heart failure in dogs
The University of Missouri Veterinary Medical Center is enrolling patients into a clinical trial evaluating the safety and effectiveness of low dose radiation therapy in the treatment of dogs diagnosed with dilated cardiomyopathy and congestive heart failure (CHF). Similar treatments in mice have shown improvement in heart function through a reduction in scar tissue and decreasing inflammation which is usually worsened with progressive aspects of cardiac disease.
Inclusion criteria:
- Any breed and weight of dogs diagnosed with idiopathic dilated cardiomyopathy
- First time congestive heart failure (right or left sided)
- Radiation therapy must be administered within 2 months of CHF diagnosis
- No taurine deficiency – golden retrievers and cocker spaniels must have whole blood levels checked
- No known cancer within the chest
- Normal thyroid function within the last 6 months or at the time of diagnosis
- No diet history including legume/pulse ingredients in the first 5 ingredients
Benefits:
- The study covers the cost associated with the administration of a single dose of radiation therapy. This includes examination, anesthesia, radiation planning, radiation therapy, echocardiogram, and cardiac troponin-I blood test.
- Recheck visits every 3 months with the cardiology service will be performed. The owner is responsible for recheck exams, blood panels, and blood pressures. The study will cover the echocardiogram, Holter monitor (24 hour electrocardiogram), and cardiac troponin-I blood test.
To participate:
- Pet owners must be willing to transport their dog to and from the treatment center in Columbia, MO for every visit abiding by specific timelines.
- A full cardiovascular screening will be performed prior to enrollment.
- The owner is responsible for initial assessment, consultation, bloodwork, chest x-rays, and echocardiogram to determine eligibility for the trial. Once your dog is eligible and enrolled in the study, an initial Holter monitor will be covered by the study.
- Participation will require a year commitment.
