The MU-Veterinary Health Center (VHC) is currently seeking patients for enrollment in funded cardiology clinical trials. Study goals and suitability for each patient are discussed in detail with the clients prior to enrollment. Although clinical trial enrollment may not be the best option for all patients, in many cases, clinical trial participation provides the opportunity to receive novel, cutting-edge therapies free of charge or at a reduced cost and may facilitate treatment of pets where it would not otherwise be possible due to financial constraints or lack of other therapy options. Criteria for enrollment are outlined for each open trial below. Please direct referrals or questions to Alyssa Lansdorf or Amanda Alvisio at 573-882-7821.
The true prevalence of cachexia in canine patients has not been determined, due in part to euthanasia when a pet’s quality of life declines and weight loss ensues. The objectives for this study are to determine toxicity, including cardiovascular effects of the final drug candidate of MC4 peptide receptor antagonist and to determine preliminary efficacy of MC4 peptide receptor antagonist in dogs with cachexia.
- History of 5% or greater with loss within past three months
- Washout of 2 days required for appetite stimulants.
- CBC, chemistry panel, UA, and abdominal ultrasound within 14 days of enrollment
- Corticosteriod use allowed if > 14 days prior to enrollment
- renal failure or liver dysfunction
- Use of appetite stimulants
- Initial visit-Blood work, echocardiogram, 24 hour holter monitor, blood pressure.
- Subsequent visit: Photos, followed by subcutaneous administration of MC4 peptide receptor antagonist, 24 hr PK sampling post drug administration.
- Daily subcutaneous administration of MC4 peptide receptor antagonist by owner.
- CBC, chemistry panel, UA and 1 hr PK- week 2 and week 4
- Holter monitor and blood pressure repeated at week 4
- Owner to complete daily diary
Benefit: Owner to pay initial office visit. Study covers initial screening, including the echocardiogram and holter monitor, office visits, blood work, cost of monitoring and treatment.
Contact Faculty Person: Dr. Stacey Leach